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CeTF is a publicly available Bioconductor package available from . Documentation is available on the Bioconductor website, and we provide vignettes describing more example analyses. We also maintain a public github repository (), and invite the community to submit or request additional functionality to incorporate into this package. This package requires R ≥4.
3. to evaluate the effectiveness of the independent and internal audits, including in regard to compliance with normative provisions applicable to us, in addition to internal regulation and codes;
CeTF is a tool that assists the identification of meaningful gene-gene associations and the main TFs in co-expression networks, as demonstrated previously. It offers functions for a complete and customizable workflow from count or expression data to networks and visualizations in a freely available R package. We expect that CeTF will be widely used by the genomics and transcriptomics community and scientists who work with high-throughput data to understand how main TFs are working in a co-expression network and what are the pathways involved in this context.
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Transcriptome analysis has become crucial to identify gene circuits involved in regulating cancer hallmarks [1]. One of the intelligent ways to explore this type of data and obtain biologically relevant information about the mechanisms involved in modulating gene circuits is the inference of gene regulatory networks (GRNs). Conceptually, we can define GRN as the reconstruction of gene networks from gene expression data, revealing the connection of transcription factors (TFs) with their targets [2], aiming to highlight which gene interactions are the most relevant to the study. Despite the plethora of tools, new methods are needed to assess all possible interactions and their significance [3].
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material.
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A aprendizagem e adopção dos temas abordados neste livro constituem uma vantagem decisiva para ESTES intervenientes qual ESTES adoptarem consistentemente.
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